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Design, synthesis and HIV-RT inhibitory activity of novel thiazolidin-4-one derivatives

Hua CHEN, Zaihong GUO, Qingmei YIN, Xiaoxu DUAN, Yunjing GU, Xiaoliu LI

Frontiers of Chemical Science and Engineering 2011, Volume 5, Issue 2,   Pages 231-237 doi: 10.1007/s11705-010-1022-7

Abstract: methyl ( and ) at C-5 on thiazolidin-4-one ring were designed, synthesized and evaluated for their HIV-RTPreliminary anti-HIV-RT test of these derivatives indicated that compounds – , (propionyloxy groupat C-5) showed moderate HIV-RT inhibitory activity and compounds and with methyl at C-5 showed aweak HIV-RT inhibitory activity.to anti-HIV-RT activity and that the steric effect might play a critical role in the anti-HIV RT activity

Keywords： 5-subsituted thiazolidin-4-ones     Pummerer reaction     anti-HIV-RT activity     SARs    

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QUANTITATIVE STUDY ON ANTI-PEST ACTIVITY OF NATURAL PRODUCTS BASED ON VISUALIZATION FRAMEWORK OF KNOWLEDGE

Frontiers of Agricultural Science and Engineering 2023, Volume 10, Issue 2,   Pages 306-332 doi: 10.15302/J-FASE-2023488

Abstract:

● Using visual analysis to predict the trend of natural product pest resistance.

Keywords： anti-pest activity     crop protection     insect pest     natural product     visual analysis    

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Smartphone-Imaged HIV-1 Reverse-Transcription Loop-Mediated Isothermal Amplification (RT-LAMP) on a Chip Article

Gregory L. Damhorst,Carlos Duarte-Guevara,Weili Chen,Tanmay Ghonge,Brian T. Cunningham,Rashid Bashir

Engineering 2015, Volume 1, Issue 3,   Pages 324-335 doi: 10.15302/J-ENG-2015072

Abstract: measurements are an essential tool for the long-term clinical care of human immunodeficiency virus (HIVpoor healthcare infrastructure, including parts of the world that are disproportionately affected by HIVprocessed HIV-spiked whole blood samples with a microfluidic and silicon microchip platform, and performof viral load from a finger prick of blood in the clinical care of HIV-positive individuals.We demonstrate that all aspects of this viral load approach, from a drop of blood to imaging the RT-LAMP

Keywords： human immunodeficiency virus (HIV)     viral load     loop-mediated isothermal amplification     smartphone     point-of-care    

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Rapamycin enhances the anti-tumor activity of cabozantinib in cMet inhibitor-resistant hepatocellular

Frontiers of Medicine 2022, Volume 16, Issue 3,   Pages 467-482 doi: 10.1007/s11684-021-0869-y

Abstract: Cabozantinib, mainly targeting cMet and vascular endothelial growth factor receptor 2, is the second-line treatment for patients with advanced hepatocellular carcinoma (HCC). However, the lower response rate and resistance limit its enduring clinical benefit. In this study, we found that cMet-low HCC cells showed primary resistance to cMet inhibitors, and the combination of cabozantinib and mammalian target of rapamycin (mTOR) inhibitor, rapamycin, exhibited a synergistic inhibitory effect on the in vitro cell proliferation and in vivo tumor growth of these cells. Mechanically, the combination of rapamycin with cabozantinib resulted in the remarkable inhibition of AKT, extracellular signal-regulated protein kinases, mTOR, and common downstream signal molecules of receptor tyrosine kinases; decreased cyclin D1 expression; and induced cell cycle arrest. Meanwhile, rapamycin enhanced the inhibitory effects of cabozantinib on the migration and tubule formation of human umbilical vascular endothelial cells and human growth factor-induced invasion of cMet inhibitor-resistant HCC cells under hypoxia condition. These effects were further validated in xenograft models. In conclusion, our findings uncover a potential combination therapy of cabozantinib and rapamycin to combat cabozantinib-resistant HCC.

Keywords： hepatocellular carcinoma     cabozantinib     primary resistance     rapamycin    

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Pregnancy outcome analysis of HIV infected women in Xinjiang， 2010—2013

Shawuli∙Ailika,Aibibai∙Maimaitiming,Wang Xiaojun

Strategic Study of CAE 2015, Volume 17, Issue 6,   Pages 50-52

Abstract:

To understand pregnancy outcomes of HIV infected women in Xinjiang.We collected and analyzed 2256 HIV infected women reported by PMTCT management information reportingunemployed), first marriage( 56.12 %), remarried ( 37.19%). 2 times or more pregnancies ( 69.68%), 316 HIVinfected women didn’t stop pregnancy after knowing their HIV infected status, accounts for 14.01%The research suggest that we should strengthen counseling and services and contraception for HIV-infected

Keywords： HIV infected pregnant women     unwilling pregnancy     reproductive health    

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Broadly neutralizing antibodies and vaccine design against HIV-1 infection

Qian Wang, Linqi Zhang

Frontiers of Medicine 2020, Volume 14, Issue 1,   Pages 30-42 doi: 10.1007/s11684-019-0721-9

Abstract: achieved for prophylactic and therapeutic interventions against human immunodeficiency virus type I (HIVStructural and dynamic studies revealed several vulnerable sites and states of the HIV-1 envelop glycoproteinOur review aims to highlight these discoveries and rejuvenate our endeavor in HIV-1 vaccine design and

Keywords： HIV-1     broadly neutralizing antibodies     Env conformational states     vaccine design     SOSIP    

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quantification of 3′-terminal 2′-O-methylated small RNAs by utilizing oxidative deep sequencing and stem-loop RT-qPCR

Frontiers of Medicine 2022, Volume 16, Issue 2,   Pages 240-250 doi: 10.1007/s11684-021-0909-7

Abstract: levels of these small RNAs is difficult because 2′-O-methylation at the RNA 3′-terminus inhibits the activityWe further compared the efficiency of stem-loop and poly(A)-tailed RT-qPCR in quantifying plant miRNAsin animal tissues and identified stem-loop RT-qPCR as the only suitable approach.Likewise, stem-loop RT-qPCR was superior to poly(A)-tailed RT-qPCR in quantifying 3′-terminal 2′-O-methyl

Keywords： small RNAs     2′-O-methylation     sequencing     RT-qPCR    

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Redesigned Duplex RT-qPCR for the Detection of GI and GII Human Noroviruses Article

Danlei Liu, Zilei Zhang, Qingping Wu, Peng Tian, Haoran Geng, Ting Xu, Dapeng Wang

Engineering 2020, Volume 6, Issue 4,   Pages 442-448 doi: 10.1016/j.eng.2019.08.018

Abstract: In this study, a new duplex RT-qPCR (ND-RT-qPCR) was designed for the detection of genogroup RT-qPCR (Kageyama RT-qPCR) for 23 HuNoV-positive clinical samples., whereas only two samples were registered as positive by Kageyama RT-qPCR., while 17 samples were registered as positive by Kageyama RT-qPCR.The sensitivity reflected by the Cq value was lower in ND-RT-qPCR than in Kageyama RT-qPCR.

Keywords： Human noroviruses     RT-qPCR     Redesign     Primer     Probe     Detection    

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Practices, challenges, and opportunities: HIV/AIDS treatment with traditional Chinese medicine in China

Jian Wang, Wen Zou

Frontiers of Medicine 2011, Volume 5, Issue 2,   Pages 123-126 doi: 10.1007/s11684-011-0124-z

Abstract: In this article, we summarize the recent major developments in human immunodeficiency virus/AIDS (HIVThe use of TCM is associated with preventing or alleviating HIV-related symptoms, reducing treatment

Keywords： HIV/AIDS     traditional Chinese medicine    

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Irreversible phenotypic perturbation and functional impairment of B cells during HIV-1 infection

Jingjing Yan, Shuye Zhang, Jun Sun, Jianqing Xu, Xiaoyan Zhang

Frontiers of Medicine 2019, Volume 13, Issue 3,   Pages 409-409 doi: 10.1007/s11684-018-0618-z

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Marriage analysis of HIV infected pregnant women

Shawuli·Ailika,Wang Xiaojun and Aibibai·Maimaitiming

Strategic Study of CAE 2014, Volume 16, Issue 5,   Pages 60-62

Abstract:

This paper aims at understanding the marriage situation of HIV infectedof HIV maternal-neonatal transmission during 2010 to 2012，so as to provide reproductive health educationfor HIV infected women.The result shows that：The average age of 1 692 HIV infected women is 29.03，of which 53.31 % is 20～29，so it is very important to develop reproductive health education for HIV infected women.

Keywords： HIV infected pregnant women     infected women     marriage transmission     reproductive health    

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An 84-month observational study of the changes in CD4 T-lymphocyte cell count of 110 HIV/AIDS patients

Jian Wang,Biyan Liang,Xiaoping Zhang,Liran Xu,Xin Deng,Xiuhui Li,Lu Fang,Xinghua Tan,Yuxiang Mao,Guoliang Zhang,Yuguang Wang

Frontiers of Medicine 2014, Volume 8, Issue 3,   Pages 362-367 doi: 10.1007/s11684-014-0363-x

Abstract: observing the changes in CD4 T-lymphocyte cell count of 110 cases with human immunodeficiency virus (HIVInformation of 110 HIV/AIDS patients from 19 provinces and cities treated with TCM from 2004 to 2013Long-term use of TCM could maintain or slow the pace of declining CD4 counts in patients with HIV/AIDS

Keywords： AIDS     HIV     CD4     traditional Chinese medicine     linear models    

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Natural history of HIV infection in former plasma donors in rural China

Min ZHANG, Hong SHANG, Zhe WANG, Wei-Guo CUI, Qing-Hai HU

Frontiers of Medicine 2010, Volume 4, Issue 3,   Pages 346-350 doi: 10.1007/s11684-010-0102-x

Abstract: FPDs all have an approximate time of human immunodeficiency virus (HIV) infection during the mid-1990sFew studies about the natural history of HIV infection in these patients were performed.A retrospective cohort study was conducted based on data collected from 5484 HIV-1 infected FPDs in ShangcaiThis is the first large-scale retrospective study on the natural history of HIV infection in FPDs in

Keywords： human immunodeficiency virus (HIV)     former plasma donor     natural history     China    

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Molecular epidemiology of Cryptococcus neoformans species complex isolates from HIV-positive and HIV-negative

Min CHEN MM, Wei-Hua PAN MD, Wan-Qing LIAO MM, Xiao-Ran LI BS, Bi-Wei FENG BS, Zhe-Xue QUAN PhD, Shao-Xi WU MD, Xiao-Ping TANG MD, Zhi-Rong YAO MD,

Frontiers of Medicine 2010, Volume 4, Issue 1,   Pages 117-126 doi: 10.1007/s11684-010-0011-z

Abstract: the species complex isolates and their clinical manifestations among human immunodeficiency virus (HIV)-positive and HIV-negative patients in southeast China in the past 15 years.In HIV-positive patients, clinical isolates were grouped into molecular types VNI (75%, 15/20), VNIIThese results suggest that both HIV-positive and HIV-negative cryptococcal patients in the southeastNo strains were found in HIV-positive patients.

Keywords： Cryptococcus neoformans     Cryptococcus gattii     cryptococcosis     molecular epidemiology     molecular type     mating type    

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Dihydroartemisinin increased the abundance of by YAP1 depression that sensitizes hepatocellular carcinoma to anti-PD

Frontiers of Medicine 2023, Volume 17, Issue 4,   Pages 729-746 doi: 10.1007/s11684-022-0978-2

Abstract: The effect of anti-programmed cell death 1 (anti-PD-1) immunotherapy is limited in patients with hepatocellularThe response to anti-PD-1 treatment is associated with A. muciniphila abundance in many tumorsHere, anti-PD-1 treatment decreased A. muciniphila abundance in the colon, but increased YAP1Yap1 knockout enhanced anti-PD-1 efficacy.Our findings suggested that the combination anti-PD-1 with DHA is an effective strategy for liver tumor

Keywords： hepatocellular carcinoma     YAP1     Akkermansia muciniphila     anti-PD-1     dihydroartemisinin     bile acid    

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Title Author Date Type Operation

Design, synthesis and HIV-RT inhibitory activity of novel thiazolidin-4-one derivatives

Hua CHEN, Zaihong GUO, Qingmei YIN, Xiaoxu DUAN, Yunjing GU, Xiaoliu LI

Journal Article

QUANTITATIVE STUDY ON ANTI-PEST ACTIVITY OF NATURAL PRODUCTS BASED ON VISUALIZATION FRAMEWORK OF KNOWLEDGE

Journal Article

Smartphone-Imaged HIV-1 Reverse-Transcription Loop-Mediated Isothermal Amplification (RT-LAMP) on a Chip

Gregory L. Damhorst,Carlos Duarte-Guevara,Weili Chen,Tanmay Ghonge,Brian T. Cunningham,Rashid Bashir

Journal Article

Rapamycin enhances the anti-tumor activity of cabozantinib in cMet inhibitor-resistant hepatocellular

Journal Article

Pregnancy outcome analysis of HIV infected women in Xinjiang， 2010—2013

Shawuli∙Ailika,Aibibai∙Maimaitiming,Wang Xiaojun

Journal Article

Broadly neutralizing antibodies and vaccine design against HIV-1 infection

Qian Wang, Linqi Zhang

Journal Article

quantification of 3′-terminal 2′-O-methylated small RNAs by utilizing oxidative deep sequencing and stem-loop RT-qPCR

Journal Article

Redesigned Duplex RT-qPCR for the Detection of GI and GII Human Noroviruses

Danlei Liu, Zilei Zhang, Qingping Wu, Peng Tian, Haoran Geng, Ting Xu, Dapeng Wang

Journal Article

Practices, challenges, and opportunities: HIV/AIDS treatment with traditional Chinese medicine in China

Jian Wang, Wen Zou

Journal Article

Irreversible phenotypic perturbation and functional impairment of B cells during HIV-1 infection

Jingjing Yan, Shuye Zhang, Jun Sun, Jianqing Xu, Xiaoyan Zhang

Journal Article

Marriage analysis of HIV infected pregnant women

Shawuli·Ailika,Wang Xiaojun and Aibibai·Maimaitiming

Journal Article

An 84-month observational study of the changes in CD4 T-lymphocyte cell count of 110 HIV/AIDS patients

Jian Wang,Biyan Liang,Xiaoping Zhang,Liran Xu,Xin Deng,Xiuhui Li,Lu Fang,Xinghua Tan,Yuxiang Mao,Guoliang Zhang,Yuguang Wang

Journal Article

Natural history of HIV infection in former plasma donors in rural China

Min ZHANG, Hong SHANG, Zhe WANG, Wei-Guo CUI, Qing-Hai HU

Journal Article

Molecular epidemiology of Cryptococcus neoformans species complex isolates from HIV-positive and HIV-negative

Min CHEN MM, Wei-Hua PAN MD, Wan-Qing LIAO MM, Xiao-Ran LI BS, Bi-Wei FENG BS, Zhe-Xue QUAN PhD, Shao-Xi WU MD, Xiao-Ping TANG MD, Zhi-Rong YAO MD,

Journal Article

Dihydroartemisinin increased the abundance of by YAP1 depression that sensitizes hepatocellular carcinoma to anti-PD

Journal Article